Generating laboratory-grown heart tissue for therapeutic interventions and understanding the development of heart structure.
We focus on pediatric regenerative medicine, with core expertise in cardiac tissue, biomaterial interactions, and amniotic fluid and induced pluripotent human stem cells. We aim to have a lab culture that prepares members to be future leaders in their fields; maintains a joyful, respectful, and productive environment; and attracts outstanding graduate students and postdocs.
Everybody in the lab looks out for the safety and well-being of all lab members and is willing to speak out or help when needed.
We aim for transparency in decisions and data/publications while maintaining confidentiality as necessary. All raw data will be available and any member of the lab is free to ask why a decision is made.
Trained bioengineers are the most important product of the lab. We all help all lab members to get to the next stage of their career and to learn and grow as a biomedical engineer.
We believe in the inclusion of minority groups and strive to provide equal support to all lab members.
Our laboratory research is funded by taxpayers and donations for medical research, and we strive to advance those goals responsibly.
Our goal is to isolate stem cells from amniotic fluid before birth and create heart tissue that can be used to reconstruct the heart with the baby’s own cells after birth.
We use laboratory-grown heart tissue to understand proliferation, migration, and force generation in heart structure formation and how these are altered in genetic disease.
We investigate scaffold composition, manufacturing methods, bioreactors, and controlled release strategies to improve consistency, cost, and translation.
Associate Professor of Bioengineering
MS Candidate
MS Candidate
MS Candidate
Undergraduate
Undergraduate
Undergraduate
Undergraduate
Selected recent and foundational publications from the Jacot Lab.
Journal of Biomechanics, 113103, 2025
Blood 146, 325, 2025
Stem Cells Translational Medicine 14(7), szaf017, 2025
Tissue Engineering Part A 30(11–12), 304–313, 2024
Journal of Biomedical Materials Research Part A 112(4), 625–634, 2024
Cellular and Molecular Bioengineering 17(1), 25–34, 2024
Advanced Healthcare Materials 10(23), 2101018, 2021
Journal of Biomedical Materials Research Part B: Applied Biomaterials 104(8), 2016
ACS Nano 8(10), 9822–9832, 2014
Biophysical Journal 95(7), 3479–3487, 2008
Recent lab news, publications, and student milestones.
April 24, 2026
Congratulations to Jaelynn Roesler on a successful MS thesis defense.
2025
The lab published work on aberrant tissue mechanics and mechanotransduction during heart development in Down syndrome in Journal of Biomechanics.
2026
Alejandro Salazar and Tarren Stephens presented a poster titled Effect of Amniotic Fluid Cell Extracellular Vesicles on Macrophage Phenotype at the CU Denver Research and Creative Activities Symposium (RaCAS).
2025
The lab published work on amniotic fluid collected from vaginal birth as a source of stem cells for clinical applications and disease modeling.
We welcome inquiries from motivated undergraduate students, graduate students, and postdoctoral researchers interested in pediatric regenerative medicine, cardiac tissue engineering, stem cells, biomaterials, mechanobiology, and congenital heart disease.
Prospective lab members should send a brief email describing their research interests, relevant experience, career goals, and why they are interested in the Jacot Lab.
Contact: jeffrey.jacot@cuanschutz.edu